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 Tiger Stadium in Baton Rouge, Louisiana will host the Week 4 college football matchup between the UCLA Bruins and LSU Tigers on Saturday, September 21.

The non-conference game will be won by which team?

Take a look at these predictions and picks for the game, which will start at 12:40 p.m. MST and be broadcast on ABC (stream using this FUBO free trial).

UCLA just lost to Indiana 42–13 in their Week 3 matchup. South Carolina was defeated 36–33 by LSU.

According to BetMGM Sportsbook's college football Week 4 odds, LSU is favored by 25.5 points over UCLA.

Professional MLB daily predictions: Exclusive MLB betting information available exclusively at USA TODAY

On the moneyline, the Tigers are at -3000. It's +1300 for the Bruins.

The game has an over/under of 55.5 points.

Arizona State vs. Texas Tech; Illinois vs. Nebraska; NC State vs. Clemson; Florida vs. Mississippi State; Kansas vs. West Virginia; USC vs. Michigan; Utah vs. Oklahoma State; Tennessee vs. Oklahoma; Baylor vs. Colorado; Kansas State vs. BYU; Northwestern vs. Washington; UCLA vs. LSU; Arkansas vs. Auburn are the selected college football games for Week 4.

In the Week 4 matchup against UCLA, wager on LSU to win.

"In Baton Rouge, the celebration has already begun," writes Bill Speros. The new playoff system means that clubs must win big. This time, style points will be important. Look for the Tigers to keep piling it on here. Last week, UCLA made their Big Ten debut and was thrashed 42–13 by Indiana. Last week, LSU defeated South Carolina in a close game at Columbia, demonstrating their mettle. Keep the locals pleased by rooting for the home team to win big here.

UCLA 14, LSU 38

According to Bill Bender: "The Bruins average 3.5 yards per rush, while UCLA quarterback Ethan Garbers has a 54.1% completion percentage. When playing LSU in Death Valley, such combination is not good. The Tigers are coming off an emotional victory at South Carolina, and the line has already increased by half a point. Even so, given that LSU is 9-2 ATS as a home favorite under Brian Kelly, there is a genuine chance for a blowout. In 2021, the Bruins defeated the Tigers 38-27. The Tigers simply beat the line in reply.

LSU's chances of defeating UCLA are 88.1%.

According to the website's matchup predictor, UCLA has an 11.9% chance of defeating UCLA on Saturday.

UCLA 13, LSU 38

"LSU is the superior team in this game and seemed to find their way a week ago," writes Cameron Ross. Against a mediocre UCLA squad, expect the Tigers to dominate this game on both ends of the ball. Allow LSU to put in the effort as they defeat the Bruins at home to get their third victory of the year.


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